Comparison of Plasmin With Recombinant Tissue-Type Plasminogen Activator in Lysis of Cerebral Thromboemboli Retrieved From Patients With Acute Ischemic Stroke | Zendy

Victor J. Marder | Zendy; Aleš Blinc | Zendy; Theresa Gruber | Zendy; Gregor Tratar | Zendy; Mišo Šabovič | Zendy; Sidney Starkman | Zendy; Reza Jahan | Zendy; Gary Duckwiler | Zendy; Fernando Viñuela | Zendy; Satoshi Tateshima | Zendy; David S. Liebeskind | Zendy; Bruce Ovbiagele | Zendy; Letisha Ali | Zendy; Doojin Kim | Zendy; Nestor R. Gonzalez | Zendy; Paul Vespa | Zendy; Jeffrey L. Saver | Zendy

Open Access

Comparison of Plasmin With Recombinant Tissue-Type Plasminogen Activator in Lysis of Cerebral Thromboemboli Retrieved From Patients With Acute Ischemic Stroke

Author(s) -

Victor J. Marder,

Aleš Blinc,

Theresa Gruber,

Gregor Tratar,

Mišo Šabovič,

Sidney Starkman,

Reza Jahan,

Gary Duckwiler,

Fernando Viñuela,

Satoshi Tateshima,

David S. Liebeskind,

Bruce Ovbiagele,

Letisha Ali,

Doojin Kim,

Nestor R. Gonzalez,

Paul Vespa,

Jeffrey L. Saver

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.609198

Subject(s) - medicine , thrombolysis , plasmin , ex vivo , thrombus , stroke (engine) , plasminogen activator , tissue plasminogen activator , streptokinase , in vivo , fibrinolysis , fibrinolytic agent , d dimer , t plasminogen activator , cardiology , anesthesia , biochemistry , myocardial infarction , biology , enzyme , mechanical engineering , microbiology and biotechnology , engineering

Plasmin is a direct-acting thrombolytic with a better safety profile than recombinant tissue-type plasminogen activator (rtPA) in animal models. With the application of retrieval devices for managing acute ischemic stroke, extracted thromboemboli are available for ex vivo examination. We ask whether such thrombi are amenable to plasmin thrombolysis and whether such activity is different with rtPA.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research