Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1 | Zendy

Hana Park | Zendy; Natalia Kubicki | Zendy; Surya Gnyawali | Zendy; Yuk Cheung Chan | Zendy; Sashwati Roy | Zendy; Savita Khanna | Zendy; Chandan K. Sen | Zendy

Open Access

Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1

Author(s) -

Hana Park,

Natalia Kubicki,

Surya Gnyawali,

Yuk Cheung Chan,

Sashwati Roy,

Savita Khanna,

Chandan K. Sen

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.608547

Subject(s) - medicine , stroke (engine) , multiple drug resistance , tocotrienol , vitamin e , ischemic stroke , pharmacology , ischemia , tocopherol , drug resistance , antioxidant , biochemistry , genetics , mechanical engineering , engineering , biology , chemistry

α-Tocotrienol (TCT) represents the most potent neuroprotective form of natural vitamin E that is Generally Recognized As Safe certified by the U.S. Food and Drug Administration. This work addresses a novel molecular mechanism by which α-TCT may be protective against stroke in vivo. Elevation of intracellular oxidized glutathione (GSSG) triggers neural cell death. Multidrug resistance-associated protein 1 (MRP1), a key mediator of intracellular oxidized glutathione efflux from neural cells, may therefore possess neuroprotective functions.

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