Osteopontin Enhances Endogenous Repair After Neonatal Hypoxic–Ischemic Brain Injury | Zendy

Cindy T. J. van Velthoven | Zendy; Cobi J. Heijnen | Zendy; Frank van Bel | Zendy; Annemieke Kavelaars | Zendy

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Osteopontin Enhances Endogenous Repair After Neonatal Hypoxic–Ischemic Brain Injury

Author(s) -

Cindy T. J. van Velthoven,

Cobi J. Heijnen,

Frank van Bel,

Annemieke Kavelaars

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.608315

Subject(s) - medicine , osteopontin , endogeny , ischemic injury , ischemia , stroke (engine) , cardiology , neuroscience , pathology , mechanical engineering , engineering , biology

Hypoxic-ischemic (HI) brain injury is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. To identify molecules important for cerebral damage and repair, we investigated the growth factor-related gene expression profile after neonatal cerebral HI. We identified osteopontin (OPN) as the most highly upregulated factor early after HI. We therefore explored the role of endogenous OPN in brain damage and repair.

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