MRI Using Ferumoxytol Improves the Visualization of Central Nervous System Vascular Malformations | Zendy

Edit Dósa | Zendy; Suchita Tuladhar | Zendy; Leslie L. Muldoon | Zendy; Bronwyn E. Hamilton | Zendy; William D. Rooney | Zendy; Edward A. Neuwelt | Zendy

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MRI Using Ferumoxytol Improves the Visualization of Central Nervous System Vascular Malformations

Author(s) -

Edit Dósa,

Suchita Tuladhar,

Leslie L. Muldoon,

Bronwyn E. Hamilton,

William D. Rooney,

Edward A. Neuwelt

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.607994

Subject(s) - ferumoxytol , medicine , arteriovenous malformation , central nervous system , vascular malformation , magnetic resonance imaging , lesion , vascular anomaly , radiology , pathology

Central nervous system vascular malformations (VMs) result from abnormal vasculo- and/or angiogenesis. Cavernomas and arteriovenous malformations are also sites of active inflammation. The aim of this study was to determine whether MRI detection of VMs can be improved by administration of ferumoxytol iron oxide nanoparticle, which acts as a blood pool agent at early time points and an inflammatory marker when taken up by tissue macrophages.

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