Endothelial Nitric Oxide Synthase Mediates Endogenous Protection Against Subarachnoid Hemorrhage-Induced Cerebral Vasospasm | Zendy

Ananth K. Vellimana | Zendy; Eric Milner | Zendy; Tej D. Azad | Zendy; Michael D. Harries | Zendy; MengLiang Zhou | Zendy; Jeffrey M. Gidday | Zendy; Byung Hee Han | Zendy; Gregory J. Zipfel | Zendy

Open Access

Endothelial Nitric Oxide Synthase Mediates Endogenous Protection Against Subarachnoid Hemorrhage-Induced Cerebral Vasospasm

Author(s) -

Ananth K. Vellimana,

Eric Milner,

Tej D. Azad,

Michael D. Harries,

MengLiang Zhou,

Jeffrey M. Gidday,

Byung Hee Han,

Gregory J. Zipfel

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.607200

Subject(s) - vasospasm , enos , subarachnoid hemorrhage , medicine , nitric oxide , cerebral vasospasm , nitric oxide synthase , anesthesia , ischemia , pharmacology , endothelium

Vasospasm-induced delayed cerebral ischemia remains a major source of morbidity in patients with aneurysmal subarachnoid hemorrhage (SAH). We hypothesized that activating innate neurovascular protective mechanisms by preconditioning (PC) may represent a novel therapeutic approach against SAH-induced vasospasm and neurological deficits and, secondarily, that the neurovascular protection it provides is mediated by endothelial nitric oxide synthase (eNOS).

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