Amount but Not Pattern of Protective Sensory Stimulation Alters Recovery After Permanent Middle Cerebral Artery Occlusion | Zendy

Melissa F. Davis | Zendy; Christopher C. Lay | Zendy; Cynthia H. ChenBee | Zendy; Ron D. Frostig | Zendy

Open Access

Amount but Not Pattern of Protective Sensory Stimulation Alters Recovery After Permanent Middle Cerebral Artery Occlusion

Author(s) -

Melissa F. Davis,

Christopher C. Lay,

Cynthia H. ChenBee,

Ron D. Frostig

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.607135

Subject(s) - medicine , middle cerebral artery , stimulation , sensory system , occlusion , sensory stimulation therapy , stroke (engine) , anesthesia , cardiology , neuroscience , ischemia , mechanical engineering , engineering , biology

Using a rodent model of ischemia (permanent middle cerebral artery occlusion), our laboratory previously demonstrated that 4.27 minutes of patterned single-whisker stimulation delivered over 120 minutes can fully protect from impending damage when initiated within 2 hours of permanent middle cerebral artery occlusion ("early"). When initiated 3 hours postpermanent middle cerebral artery occlusion ("late"), stimulation resulted in irreversible damage. Here we investigate the effect of altering pattern, distribution, or amount of stimulation in this model.

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