Predicting Infarction Within the Diffusion-Weighted Imaging Lesion | Zendy

Emmanuel Carrera | Zendy; P. Simon Jones | Zendy; Josef A. Alawneh | Zendy; Irene Klærke Mikkelsen | Zendy; TaeHee Cho | Zendy; S. Siemonsen | Zendy; Joseph V. Guadagno | Zendy; Kim Mouridsen | Zendy; Lars Ribe | Zendy; Niels Hjort | Zendy; Tim D. Fryer | Zendy; T. Adrian Carpenter | Zendy; Franklin I. Aigbirhio | Zendy; Jens Fiehler | Zendy; Norbert Nighoghossian | Zendy; Elizabeth A. Warburton | Zendy; Leif Østergaard | Zendy; JeanClaude Baron | Zendy

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Predicting Infarction Within the Diffusion-Weighted Imaging Lesion

Author(s) -

Emmanuel Carrera,

P. Simon Jones,

Josef A. Alawneh,

Irene Klærke Mikkelsen,

TaeHee Cho,

S. Siemonsen,

Joseph V. Guadagno,

Kim Mouridsen,

Lars Ribe,

Niels Hjort,

Tim D. Fryer,

T. Adrian Carpenter,

Franklin I. Aigbirhio,

Jens Fiehler,

Norbert Nighoghossian,

Elizabeth A. Warburton,

Leif Østergaard,

JeanClaude Baron

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.606970

Subject(s) - medicine , voxel , nuclear medicine , positron emission tomography , diffusion mri , region of interest , stroke (engine) , perfusion , radiology , receiver operating characteristic , magnetic resonance imaging , infarction , lesion , perfusion scanning , cerebral blood flow , pathology , myocardial infarction , mechanical engineering , engineering

There is ample evidence that in anterior circulation stroke, the diffusion-weighted imaging (DWI) lesion may escape infarction and thus is not a reliable infarct predictor. In this study, we assessed the predictive value of the mean transit time (MTT) for final infarction within the DWI lesion, first in patients scanned back-to-back with 15O-positron emission tomography and MR (DWI and perfusion-weighted imaging; "Cambridge sample") within 7 to 21 hours of clinical onset, then in a large sample of patients with anterior circulation stroke receiving DWI and perfusion-weighted imaging within 12 hours (85% within 6 hours; "I-KNOW sample").

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