The CCR2/CCL2 Interaction Mediates the Transendothelial Recruitment of Intravascularly Delivered Neural Stem Cells to the Ischemic Brain | Zendy

Robert H. Andres | Zendy; Raymond Choi | Zendy; Arjun V. Pendharkar | Zendy; Xavier Gaeta | Zendy; Nancy Wang | Zendy; Jay K. Nathan | Zendy; Joshua Y. Chua | Zendy; Star W. Lee | Zendy; Theo D. Palmer | Zendy; Gary K. Steinberg | Zendy; Raphaël Guzman | Zendy

Open Access

The CCR2/CCL2 Interaction Mediates the Transendothelial Recruitment of Intravascularly Delivered Neural Stem Cells to the Ischemic Brain

Author(s) -

Robert H. Andres,

Raymond Choi,

Arjun V. Pendharkar,

Xavier Gaeta,

Nancy Wang,

Jay K. Nathan,

Joshua Y. Chua,

Star W. Lee,

Theo D. Palmer,

Gary K. Steinberg,

Raphaël Guzman

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.606368

Subject(s) - homing (biology) , medicine , ccr2 , bioluminescence imaging , transplantation , neural stem cell , ischemia , chemokine , microglia , stem cell , neuroscience , ccl2 , inflammation , immunology , chemokine receptor , microbiology and biotechnology , biology , cell culture , ecology , transfection , genetics , luciferase

The inflammatory response is a critical component of ischemic stroke. In addition to its physiological role, the mechanisms behind transendothelial recruitment of immune cells also offer a unique therapeutic opportunity for translational stem cell therapies. Recent reports have demonstrated homing of neural stem cells (NSC) into the injured brain areas after intravascular delivery. However, the mechanisms underlying the process of transendothelial recruitment remain largely unknown. Here we describe the critical role of the chemokine CCL2 and its receptor CCR2 in targeted homing of NSC after ischemia.

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