Cerebrospinal Fluid 20-HETE Is Associated With Delayed Cerebral Ischemia and Poor Outcomes After Aneurysmal Subarachnoid Hemorrhage | Zendy

Elizabeth Crago | Zendy; Bhavani P. Thampatty | Zendy; Paula R. Sherwood | Zendy; Chie-Wen J. Kuo | Zendy; Catherine M. Bender | Zendy; Jeffrey Balzer | Zendy; Michael Horowitz | Zendy; Samuel M. Poloyac | Zendy

Open Access

Cerebrospinal Fluid 20-HETE Is Associated With Delayed Cerebral Ischemia and Poor Outcomes After Aneurysmal Subarachnoid Hemorrhage

Author(s) -

Elizabeth Crago,

Bhavani P. Thampatty,

Paula R. Sherwood,

Chie-Wen J. Kuo,

Catherine M. Bender,

Jeffrey Balzer,

Michael Horowitz,

Samuel M. Poloyac

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.605816

Subject(s) - medicine , subarachnoid hemorrhage , cerebral blood flow , vasospasm , cerebrospinal fluid , cerebral vasospasm , anesthesia , ischemia , cerebral perfusion pressure , cardiology

Delayed cerebral ischemia (DCI) is a major complication after aneurysmal subarachnoid hemorrhage (aSAH); it is manifested by changes in cerebral blood flow accompanied by neurological decline, and it results in long-term functional and neuropsychological impairment. Preclinical evidence has demonstrated that the arachidonic acid metabolite, 20-hydroxyeicosatetraenoic acid (20-HETE), affects cerebral microvascular tone and cerebral blood flow after aSAH. The purpose of this study was to determine whether cerebrospinal fluid 20-HETE levels were associated with DCI and long-term neuropsychological outcomes in aSAH patients.

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