Family History of Stroke Is an Independent Risk Factor for Lacunar Stroke Subtype With Asymptomatic Lacunar Infarcts at Younger Ages | Zendy

Iris L.H. Knottnerus | Zendy; Marij Gielen | Zendy; J. Lodder | Zendy; Rob P.W. Rouhl | Zendy; Julie Staals | Zendy; Robert Vlietinck | Zendy; Robert J. van Oostenbrugge | Zendy

Open Access

Family History of Stroke Is an Independent Risk Factor for Lacunar Stroke Subtype With Asymptomatic Lacunar Infarcts at Younger Ages

Author(s) -

Iris L.H. Knottnerus,

Marij Gielen,

J. Lodder,

Rob P.W. Rouhl,

Julie Staals,

Robert Vlietinck,

Robert J. van Oostenbrugge

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.602383

Subject(s) - medicine , lacunar stroke , asymptomatic , odds ratio , stroke (engine) , risk factor , family history , proband , family aggregation , cardiology , ischemic stroke , disease , ischemia , genetics , biology , engineering , mutation , gene , mechanical engineering

Results from case-control and case-case studies indicate that a positive family history of stroke (FHstroke) is an independent risk factor for lacunar stroke. Different lacunar stroke phenotypes can be distinguished on the basis of the presence of asymptomatic lacunar infarcts (aLACs), ischemic white-matter lesions, or brain microbleeds. The aim of the present study was to determine whether familial aggregation of stroke was different for lacunar stroke phenotypes.

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