Phosphatidylinositol-3-Kinase Gamma Plays a Central Role in Blood–Brain Barrier Dysfunction in Acute Experimental Stroke | Zendy

Rong Jin | Zendy; Zifang Song | Zendy; Shiyong Yu | Zendy; A Piazza | Zendy; Anil Nanda | Zendy; Josef Penninger | Zendy; D. Neil Granger | Zendy; Guohong Li | Zendy

Open Access

Phosphatidylinositol-3-Kinase Gamma Plays a Central Role in Blood–Brain Barrier Dysfunction in Acute Experimental Stroke

Author(s) -

Rong Jin,

Zifang Song,

Shiyong Yu,

A Piazza,

Anil Nanda,

Josef Penninger,

D. Neil Granger,

Guohong Li

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.601369

Subject(s) - medicine , blood–brain barrier , proinflammatory cytokine , oxidative stress , pi3k/akt/mtor pathway , brain ischemia , ischemia , nadph oxidase , brain damage , endocrinology , inflammation , signal transduction , biochemistry , biology , central nervous system

Phosphoinositide 3-kinase (PI3K)-γ is linked to inflammation and oxidative stress. This study was conducted to investigate the role of the PI3Kγ in the blood-brain barrier dysfunction and brain damage induced by focal cerebral ischemia/reperfusion.

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