A Mouse Model of Hemorrhagic Transformation by Delayed Tissue Plasminogen Activator Administration After In Situ Thromboembolic Stroke | Zendy

Isaac GarcíaYébenes | Zendy; Mónica Sobrado | Zendy; Juan G. Zarruk | Zendy; Mar Castellanos | Zendy; Natàlia Pérez de la Ossa | Zendy; Antoni Dávalos | Zendy; Joaquı́n Serena | Zendy; Ignacio Lizasoaín | Zendy; Marı́a A. Moro | Zendy

Open Access

A Mouse Model of Hemorrhagic Transformation by Delayed Tissue Plasminogen Activator Administration After In Situ Thromboembolic Stroke

Author(s) -

Isaac GarcíaYébenes,

Mónica Sobrado,

Juan G. Zarruk,

Mar Castellanos,

Natàlia Pérez de la Ossa,

Antoni Dávalos,

Joaquı́n Serena,

Ignacio Lizasoaín,

Marı́a A. Moro

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.600452

Subject(s) - medicine , tissue plasminogen activator , anesthesia , parenchyma , occlusion , infarction , ischemia , plasminogen activator , stroke (engine) , thromboembolic stroke , cerebral infarction , middle cerebral artery , fibrinolysis , t plasminogen activator , cardiology , pathology , myocardial infarction , atrial fibrillation , mechanical engineering , engineering

hrombolytic treatment with tissue plasminogen activator (tPA) improves outcome of patients with stroke who can be treated within 3 hours of symptom onset. However, delayed treatment with tPA leads to increased risk of hemorrhagic transformation and can result in enhanced brain injury. The purpose of this study is to validate a reproducible mouse model of hemorrhagic transformation associated with delayed administration of tPA.

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