Open AccessWeighting Components of Composite End Points in Clinical Trials
Author(s) -
KeunSik Hong,
Latisha K. Ali,
Scott Selco,
Gregg C. Fonarow,
Jeffrey L. Saver
Publication year - 2011
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.110.600106
Subject(s) - medicine , weighting , composite number , clinical trial , statistics , radiology , composite material , materials science , mathematics
Conventional analysis of vascular prevention trials assigns equal weight to disparate vascular events in a composite end point at variance with the public's perception of their differential impact on health outcome. This study sought to apply the disability-adjusted life-year (DALY) metric to differential weighting individual vascular end points in trial analyses.
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