Myeloid-Specific Deletion of the Mineralocorticoid Receptor Reduces Infarct Volume and Alters Inflammation During Cerebral Ischemia | Zendy

Ryan A. Frieler | Zendy; He Meng | Zendy; Sheng Zhong Duan | Zendy; Stefan Berger | Zendy; Günther Schütz | Zendy; Yangdong He | Zendy; Guohua Xi | Zendy; Michael M. Wang | Zendy; Richard M. Mortensen | Zendy

Open Access

Myeloid-Specific Deletion of the Mineralocorticoid Receptor Reduces Infarct Volume and Alters Inflammation During Cerebral Ischemia

Author(s) -

Ryan A. Frieler,

He Meng,

Sheng Zhong Duan,

Stefan Berger,

Günther Schütz,

Yangdong He,

Guohua Xi,

Michael M. Wang,

Richard M. Mortensen

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.598441

Subject(s) - medicine , microglia , myeloid , inflammation , pathology , h&e stain , ischemia , immunology , immunohistochemistry

mineralocorticoid receptor (MR) antagonists have protective effects in rodent models of ischemic stroke, but the cell type-specific actions of these drugs are unknown. In the present study, we examined the contribution of myeloid cell MR during focal cerebral ischemia using myeloid-specific MR knockout mice.

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