NCX1 Is a Novel Target Gene for Hypoxia-Inducible Factor-1 in Ischemic Brain Preconditioning | Zendy

Valeria Valsecchi | Zendy; Giuseppe Pignataro | Zendy; Annalisa Del Prete | Zendy; Rossana Sirabella | Zendy; Carmela Matrone | Zendy; Francesca Boscia | Zendy; Antonella Scorziello | Zendy; Maria Josè Sisalli | Zendy; Elga Esposito | Zendy; Nicola Zambrano | Zendy; Gianfranco Di Renzo | Zendy; Lucio Annunziato | Zendy

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NCX1 Is a Novel Target Gene for Hypoxia-Inducible Factor-1 in Ischemic Brain Preconditioning

Author(s) -

Valeria Valsecchi,

Giuseppe Pignataro,

Annalisa Del Prete,

Rossana Sirabella,

Carmela Matrone,

Francesca Boscia,

Antonella Scorziello,

Maria Josè Sisalli,

Elga Esposito,

Nicola Zambrano,

Gianfranco Di Renzo,

Lucio Annunziato

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.597583

Subject(s) - medicine , ischemic preconditioning , hypoxia (environmental) , ischemic stroke , hypoxia inducible factors , hypoxia inducible factor 1 , stroke (engine) , pharmacology , neuroscience , gene , cardiology , ischemia , transcription factor , genetics , oxygen , chemistry , organic chemistry , biology , mechanical engineering , engineering

The sodium-calcium exchanger-1 (NCX1) represents a key mediator for maintaining [Na(+)](i) and [Ca(2+)](i) homeostasis. Although changes in NCX1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still unknown. Thus far, however, there is evidence that hypoxia-inducible factor-1 (HIF-1) is a nuclear factor required for transcriptional activation of several genes implicated in stroke. The main objective of this study was to investigate whether NCX1 gene might be a novel target of HIF-1 in the brain.

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