Advanced Contrast-Enhanced MRI for Looking Beyond the Lumen to Predict Stroke | Zendy

Bruce A. Wasserman | Zendy

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Advanced Contrast-Enhanced MRI for Looking Beyond the Lumen to Predict Stroke

Author(s) -

Bruce A. Wasserman

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.596288

Subject(s) - medicine , fibrous cap , risk stratification , radiology , stroke (engine) , lumen (anatomy) , gadolinium , angiography , contrast (vision) , mechanical engineering , materials science , artificial intelligence , computer science , engineering , metallurgy

Carotid plaque MRI can identify components indicative of stroke risk, including the thin/ruptured fibrous cap and lipid core. Gadolinium contrast, typically administered for routine MR angiography acquisitions, can be used to improve plaque characterization, extending risk assessment beyond the plaque's hemodynamic impact on the lumen. Gadolinium preferentially enhances the cap, improves reliability of vessel wall measurements, and highlights neovessels, improving stroke risk stratification. Additionally, the precontrast series from the contrast-enhanced MR angiography can help identify intraplaque hemorrhage, another important risk marker. Prospective validation of these features is needed to develop a carotid plaque risk profile for clinical implementation.

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