Early Experience of Translating pH-Weighted MRI to Image Human Subjects at 3 Tesla | Zendy

Phillip Zhe Sun | Zendy; Thomas Benner | Zendy; William A. Copen | Zendy; A. Gregory Sorensen | Zendy

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Early Experience of Translating pH-Weighted MRI to Image Human Subjects at 3 Tesla

Author(s) -

Phillip Zhe Sun,

Thomas Benner,

William A. Copen,

A. Gregory Sorensen

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.595777

Subject(s) - penumbra , medicine , diffusion mri , magnetic resonance imaging , brain tissue , perfusion , nuclear medicine , stroke (engine) , human brain , ischemic stroke , radiology , ischemia , biomedical engineering , mechanical engineering , psychiatry , engineering

In acute stroke, mismatch between lesions seen on diffusion- (DWI) and perfusion-weighted (PWI) MRI has been used to identify ischemic tissue before irreversible damage. Nevertheless, the concept of PWI/DWI mismatch is oversimplified and the ischemic tissue metabolic status and outcome are often heterogeneous. Tissue pH, a well-regulated physiological index that alters on disrupted tissue metabolism, may provide a surrogate metabolic imaging marker that augments the DWI and PWI for penumbra imaging.

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