Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Streptozotocin-Induced Diabetic Rats | Zendy

Kunjan R. Dave | Zendy; John Tamariz | Zendy; K. Desai | Zendy; Frank Brand | Zendy; Annie Liu | Zendy; Isabel Saul | Zendy; Sanjoy K. Bhattacharya | Zendy; Antonello Pileggi | Zendy

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Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Streptozotocin-Induced Diabetic Rats

Author(s) -

Kunjan R. Dave,

John Tamariz,

K. Desai,

Frank Brand,

Annie Liu,

Isabel Saul,

Sanjoy K. Bhattacharya,

Antonello Pileggi

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.594937

Subject(s) - medicine , streptozotocin , hypoglycemia , ischemic stroke , diabetes mellitus , cardiology , anesthesia , ischemia , endocrinology

Stroke and heart disease are the most serious complications of diabetes accounting for >65% of mortality among diabetics. Although intensive insulin therapy has significantly improved the prognosis of diabetes and its complications, it is associated with an elevated risk of recurrent hypoglycemia (RH). We tested the hypothesis that RH exacerbates cerebral ischemic damage in a rodent model of diabetes.

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