Maps of Time to Maximum and Time to Peak for Mismatch Definition in Clinical Stroke Studies Validated With Positron Emission Tomography | Zendy

Olivier ZaroWeber | Zendy; Walter MoellerHartmann | Zendy; Wolf-Dieter Heiß | Zendy; Jan Sobesky | Zendy

Open Access

Maps of Time to Maximum and Time to Peak for Mismatch Definition in Clinical Stroke Studies Validated With Positron Emission Tomography

Author(s) -

Olivier ZaroWeber,

Walter MoellerHartmann,

Wolf-Dieter Heiß,

Jan Sobesky

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.594432

Subject(s) - interquartile range , medicine , nuclear medicine , receiver operating characteristic , positron emission tomography , penumbra , stroke (engine) , cerebral blood flow , area under the curve , mann–whitney u test , perfusion scanning , perfusion , radiology , ischemia , physics , thermodynamics

Perfusion-weighted imaging-derived maps of time-to-maximum (Tmax) are increasingly used to identify the tissue at risk in clinical stroke studies (eg, DEFUSE and EPITHET). Using quantitative positron emission tomography (PET), we evaluated Tmax to define the penumbral flow threshold in stroke patients and compared its performance to nondeconvolved time-to-peak (TTP) maps.

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