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Bone marrow stromal cells (BMSC) decrease neurological deficits in rodents after stroke and concomitantly induce extensive neurite remodeling in the brain, which highly correlates with the improvement of neurological function. We investigated the effects of endogenous tissue plasminogen activator (tPA) on neurite remodeling after BMSC treatment.

Endogenous Tissue Plasminogen Activator Mediates Bone Marrow Stromal Cell-Induced Neurite Remodeling After Stroke in Mice