Endogenous Tissue Plasminogen Activator Mediates Bone Marrow Stromal Cell-Induced Neurite Remodeling After Stroke in Mice | Zendy

Li Shen | Zendy; Hongqi Xin | Zendy; Yi Li | Zendy; Rui Lan Zhang | Zendy; Yisheng Cui | Zendy; Li Zhang | Zendy; Mei Lü | Zendy; Zheng Gang Zhang | Zendy; Michael Chopp | Zendy

Open Access

Endogenous Tissue Plasminogen Activator Mediates Bone Marrow Stromal Cell-Induced Neurite Remodeling After Stroke in Mice

Author(s) -

Li Shen,

Hongqi Xin,

Yi Li,

Rui Lan Zhang,

Yisheng Cui,

Li Zhang,

Mei Lü,

Zheng Gang Zhang,

Michael Chopp

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.593863

Subject(s) - medicine , tissue plasminogen activator , neurite , bone marrow , stromal cell , stroke (engine) , striatum , ischemia , endocrinology , endogeny , biology , mechanical engineering , dopamine , biochemistry , engineering , in vitro

Bone marrow stromal cells (BMSC) decrease neurological deficits in rodents after stroke and concomitantly induce extensive neurite remodeling in the brain, which highly correlates with the improvement of neurological function. We investigated the effects of endogenous tissue plasminogen activator (tPA) on neurite remodeling after BMSC treatment.

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