Tumor Necrosis Factor-α Enhances Microvascular Tone and Reduces Blood Flow in the Cochlea via Enhanced Sphingosine-1-Phosphate Signaling | Zendy

Elias Q. Scherer | Zendy; Jing Yang | Zendy; Martin Canis | Zendy; Katrin Reimann | Zendy; K. Ivanov | Zendy; Christian Diehl | Zendy; Peter H. Backx | Zendy; W. Gil Wier | Zendy; Sebastian Strieth | Zendy; Philine Wangemann | Zendy; Julia VoigtlaenderBolz | Zendy; Darcy Lidington | Zendy; SteffenSebastian Bolz | Zendy

Open Access

Tumor Necrosis Factor-α Enhances Microvascular Tone and Reduces Blood Flow in the Cochlea via Enhanced Sphingosine-1-Phosphate Signaling

Author(s) -

Elias Q. Scherer,

Jing Yang,

Martin Canis,

Katrin Reimann,

K. Ivanov,

Christian Diehl,

Peter H. Backx,

W. Gil Wier,

Sebastian Strieth,

Philine Wangemann,

Julia VoigtlaenderBolz,

Darcy Lidington,

SteffenSebastian Bolz

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.593327

Subject(s) - medicine , spiral ligament , spiral ganglion , organ of corti , tumor necrosis factor alpha , endocrinology , intravital microscopy , cochlea , pathology , microcirculation , anatomy

We sought to demonstrate that tumor necrosis factor (TNF)-α, via sphingosine-1-phosphate signaling, has the potential to alter cochlear blood flow and thus, cause ischemic hearing loss.

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