Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease | Zendy

Rob P.W. Rouhl | Zendy; Robert J. van Oostenbrugge | Zendy; Ruud Theunissen | Zendy; Iris L.H. Knottnerus | Zendy; Julie Staals | Zendy; Léon H.G. Henskens | Zendy; Abraham A. Kroon | Zendy; Peter W. de Leeuw | Zendy; J. Lodder | Zendy; Jan-Willem Cohen Tervaert | Zendy; Jan Damoiseaux | Zendy

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Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease

Author(s) -

Rob P.W. Rouhl,

Robert J. van Oostenbrugge,

Ruud Theunissen,

Iris L.H. Knottnerus,

Julie Staals,

Léon H.G. Henskens,

Abraham A. Kroon,

Peter W. de Leeuw,

J. Lodder,

Jan-Willem Cohen Tervaert,

Jan Damoiseaux

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.592725

Subject(s) - medicine , autoantibody , pathogenesis , antibody , lacunar stroke , lipoprotein , endothelial dysfunction , stroke (engine) , pathology , immunology , cholesterol , ischemic stroke , ischemia , mechanical engineering , engineering

Oxidized low-density lipoprotein (oxLDL) induces endothelial dysfunction and antibody formation. Because endothelial dysfunction is involved in cerebral small vessel disease (CSVD) (dilated Virchow Robin spaces, lacunar infarcts, and white matter lesions), oxLDL antibodies could play a role in CSVD pathogenesis. Therefore, we studied oxLDL antibodies in patients with high prevalence of CSVD: lacunar stroke patients and essential hypertensive patients.

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