Glucocorticoid Insensitivity at the Hypoxic Blood–Brain Barrier Can Be Reversed by Inhibition of the Proteasome | Zendy

Christoph Kleinschnitz | Zendy; Kinga Blecharz | Zendy; Timo Kahles | Zendy; Tobias Schwarz | Zendy; Peter Kraft | Zendy; Kerstin Göbel | Zendy; Sven G. Meuth | Zendy; Małgorzata Burek | Zendy; Thomas Thum | Zendy; Guido Stoll | Zendy; Carola Y. Förster | Zendy

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Glucocorticoid Insensitivity at the Hypoxic Blood–Brain Barrier Can Be Reversed by Inhibition of the Proteasome

Author(s) -

Christoph Kleinschnitz,

Kinga Blecharz,

Timo Kahles,

Tobias Schwarz,

Peter Kraft,

Kerstin Göbel,

Sven G. Meuth,

Małgorzata Burek,

Thomas Thum,

Guido Stoll,

Carola Y. Förster

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.592238

Subject(s) - medicine , blood–brain barrier , glucocorticoid , dexamethasone , glucocorticoid receptor , hypoxia (environmental) , transactivation , bortezomib , endocrinology , pharmacology , central nervous system , biology , chemistry , gene expression , biochemistry , organic chemistry , oxygen , multiple myeloma , gene

Glucocorticoids potently stabilize the blood-brain barrier and ameliorate tissue edema in certain neoplastic and inflammatory disorders of the central nervous system, but they are largely ineffective in patients with acute ischemic stroke. The reasons for this discrepancy are unresolved.

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