Letter Regarding Brouns et al, Baptista et al, and Wozniak et al

To The Editor:We congratulate the authors of the 3 recent studies addressing the prevalence of Fabry disease (FD) in stroke.1,–,3 Previous studies provided conflicting results with no practical conclusion.4,5 However, early diagnosis of FD could be crucial because enzyme replacement therapy may prevent severe disease manifestations.6 The 3 studies differ according to populations enrolled.1,–,3 Two studies considered ischemic or hemorrhagic strokes,1,2 although the relation between FD and hemorrhagic stroke is unclear. Moreover, these 2 studies included patients regardless of stroke etiology, which may have led to underestimation of FD. The other study considered cryptogenic ischemic strokes only, but there was no definition for cryptogenic stroke.3 Women were investigated in 2 studies only.1,2 The studies also differed according …