Critical Roles of Macrophages in the Formation of Intracranial Aneurysm | Zendy

Yasuhisa Kanematsu | Zendy; Miyuki Kanematsu | Zendy; Chie Kurihara | Zendy; Yoshiteru Tada | Zendy; Tsung-Ling Tsou | Zendy; Nico van Rooijen | Zendy; Michael T. Lawton | Zendy; William L. Young | Zendy; Elena I. Liang | Zendy; Yoshitsugu Nuki | Zendy; Tomoki Hashimoto | Zendy

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Critical Roles of Macrophages in the Formation of Intracranial Aneurysm

Author(s) -

Yasuhisa Kanematsu,

Miyuki Kanematsu,

Chie Kurihara,

Yoshiteru Tada,

Tsung-Ling Tsou,

Nico van Rooijen,

Michael T. Lawton,

William L. Young,

Elena I. Liang,

Yoshitsugu Nuki,

Tomoki Hashimoto

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.590976

Subject(s) - medicine , aneurysm , macrophage , inflammation , elastase , infiltration (hvac) , matrix metalloproteinase , chemokine , pathology , monocyte , pathophysiology , ccr2 , cerebrospinal fluid , immunology , surgery , biology , chemokine receptor , in vitro , enzyme , biochemistry , physics , thermodynamics

abnormal vascular remodeling triggered by hemodynamic stresses and inflammation is believed to be a key process in the pathophysiology of intracranial aneurysms. Numerous studies have shown infiltration of inflammatory cells, especially macrophages, into intracranial aneurysmal walls in humans. Using a mouse model of intracranial aneurysms, we tested whether macrophages play critical roles in the formation of intracranial aneurysms.

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