Open AccessWhole Brain and Regional Hyperintense White Matter Volume and Blood Pressure
Author(s) -
Peter Kochunov,
David C. Glahn,
Jack L. Lancaster,
Anderson M. Winkler,
Jack W. Kent,
Rene L. Olvera,
Shelley A. Cole,
Thomas D. Dyer,
Laura Almasy,
Ravi Duggirala,
Peter T. Fox,
John Blangero
Publication year - 2010
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.110.590943
Subject(s) - quantitative trait locus , white matter , pulse pressure , medicine , blood pressure , locus (genetics) , population , heritability , brain size , neuroimaging , genetics , biology , gene , magnetic resonance imaging , radiology , environmental health , psychiatry
The volume of T2-hyperintense white matter (HWM) is an important neuroimaging marker of cerebral integrity with a demonstrated high heritability. Pathophysiology studies have shown that the regional, ependymal, and subcortical HWM lesions are associated with elevated arterial pulse pressure and arterial blood pressure (BP), respectively. We performed bivariate, whole-genome linkage analyses for HWM volumes and BP measurements to identify chromosomal regions that contribute jointly to both traits in a population of healthy Mexican Americans. Our aims were to localize novel quantitative trait loci acting pleiotropically on these phenotypes and to replicate previous genetic findings on whole brain HWM volume and BP measurements.
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