Effects of Metformin in Experimental Stroke | Zendy

Jun Li | Zendy; Sharon E. Benashski | Zendy; Venugopal Reddy Venna | Zendy; Louise D. McCullough | Zendy

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Effects of Metformin in Experimental Stroke

Author(s) -

Jun Li,

Sharon E. Benashski,

Venugopal Reddy Venna,

Louise D. McCullough

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.589697

Subject(s) - medicine , metformin , stroke (engine) , diabetes mellitus , endocrinology , mechanical engineering , engineering

Adenosine 5'-monophosphate-activated protein kinase (AMPK) is an important sensor of energy balance. Stroke-induced AMPK activation is deleterious because both pharmacological inhibition and genetic deletion of AMPK are neuroprotective. Metformin is a known AMPK activator but reduces stroke incidence in clinical populations. We investigated the effect of acute and chronic metformin treatment on infarct volume and AMPK activation in experimental stroke.

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