Neuroprotective Effect of Bax-Inhibiting Peptide on Neonatal Brain Injury | Zendy

Xiaoyang Wang | Zendy; Wei Han | Zendy; Xiaonan Du | Zendy; Changlian Zhu | Zendy; Ylva Carlsson | Zendy; Carina Mallard | Zendy; Étienne Jacotot | Zendy; Henrik Hagberg | Zendy

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Neuroprotective Effect of Bax-Inhibiting Peptide on Neonatal Brain Injury

Author(s) -

Xiaoyang Wang,

Wei Han,

Xiaonan Du,

Changlian Zhu,

Ylva Carlsson,

Carina Mallard,

Étienne Jacotot,

Henrik Hagberg

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.589051

Subject(s) - neuroprotection , medicine , peptide , stroke (engine) , pharmacology , neuroscience , biochemistry , biology , mechanical engineering , chemistry , engineering

Mitochondria play a critical role in mediating cell death in both the adult and immature brain. The cyclophilin D mitochondrial membrane permeability transition pore is critical in adult ischemia, whereas in neonatal hypoxic-ischemic (HI) brain injury, mitochondrial permeabilization appears to be primarily Bax-dependent. The aim of this study was to evaluate the neuroprotective effect of a cell-penetrating Bax-inhibiting peptide (BIP) on neonatal mouse HI brain injury.

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