Effect of Prenatal Glucocorticoids on Cerebral Vasculature of the Developing Brain | Zendy

Govindaiah Vinukonda | Zendy; Krishna Dummula | Zendy; Sabrina Malik | Zendy; Furong Hu | Zendy; Carl I. Thompson | Zendy; Anna Csiszár | Zendy; Zoltán Ungvári | Zendy; Praveen Ballabh | Zendy

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Effect of Prenatal Glucocorticoids on Cerebral Vasculature of the Developing Brain

Author(s) -

Govindaiah Vinukonda,

Krishna Dummula,

Sabrina Malik,

Furong Hu,

Carl I. Thompson,

Anna Csiszár,

Zoltán Ungvári,

Praveen Ballabh

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.588400

Subject(s) - glial fibrillary acidic protein , angiogenesis , vascular endothelial growth factor , germinal matrix , endocrinology , glucocorticoid , pericyte , medicine , growth factor , gliosis , endothelial stem cell , biology , pathology , immunohistochemistry , intraventricular hemorrhage , pregnancy , biochemistry , receptor , in vitro , vegf receptors , genetics , gestational age

Prenatal glucocorticoids prevent germinal matrix hemorrhage in premature infants. The underlying mechanism, however, is elusive. Germinal matrix is enriched with angiogenic vessels exhibiting paucity of pericytes and glial fibrillary acidic protein-positive astrocyte end feet. Therefore, we asked whether glucocorticoid treatment would suppress angiogenesis and enhance periendothelial coverage by pericytes and glial fibrillary acidic protein-positive end feet in the germinal matrix microvasculature.

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