Differential Effects of Chromosome 9p21 Variation on Subphenotypes of Intracranial Aneurysm | Zendy

Hirofumi Nakaoka | Zendy; Tomoko Takahashi | Zendy; Koichi Akiyama | Zendy; Tailin Cui | Zendy; Atsushi Tajima | Zendy; Boris Krischek | Zendy; Hidetoshi Kasuya | Zendy; Akira Hata | Zendy; Ituro Inoue | Zendy

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Differential Effects of Chromosome 9p21 Variation on Subphenotypes of Intracranial Aneurysm

Author(s) -

Hirofumi Nakaoka,

Tomoko Takahashi,

Koichi Akiyama,

Tailin Cui,

Atsushi Tajima,

Boris Krischek,

Hidetoshi Kasuya,

Akira Hata,

Ituro Inoue

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.586529

Subject(s) - medicine , single nucleotide polymorphism , aneurysm , locus (genetics) , logistic regression , confounding , allele , subarachnoid hemorrhage , case control study , gastroenterology , genetics , genotype , surgery , gene , biology

Recently, a genome-wide association study identified associations between single nucleotide polymorphisms on chromosome 9p21 and risk of harboring intracranial aneurysm (IA). Aneurysm characteristics or subphenotypes of IAs, such as history of subarachnoid hemorrhage, presence of multiple IAs and location of IAs, are clinically important. We investigated whether the association between 9p21 variation and risk of IA varied among these subphenotypes.

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