Open AccessThrombin Mediates Severe Neurovascular Injury During Ischemia
Author(s) -
Bo Chen,
Qun Cheng,
Kai Yang,
Patrick D. Lyden
Publication year - 2010
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.110.584920
Subject(s) - medicine , extravasation , thrombin , ischemia , vascular permeability , anesthesia , pharmacology , argatroban , fibrin , pathology , platelet , immunology
Cerebral ischemia initiates cascades of pathological events such as edema, blood-brain barrier breakdown, and tissue degeneration. Thrombin activation is a key step in coagulation, and thrombin has recently been shown to mediate endothelial permeability and cellular toxicity in vitro. We examined the effect of thrombin on vasculature during ischemia in vivo.
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