Graphic Reanalysis of the Two NINDS-tPA Trials Confirms Substantial Treatment Benefit | Zendy

Jeffrey L. Saver | Zendy; Jeffrey Gornbein | Zendy; Sidney Starkman | Zendy

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Graphic Reanalysis of the Two NINDS-tPA Trials Confirms Substantial Treatment Benefit

Author(s) -

Jeffrey L. Saver,

Jeffrey Gornbein,

Sidney Starkman

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.583807

Subject(s) - medicine , interquartile range , stroke (engine) , placebo , thrombolysis , fibrinolytic agent , statistics , surgery , tissue plasminogen activator , mathematics , mechanical engineering , alternative medicine , pathology , myocardial infarction , engineering

Multiple statistical analyses of the 2 NINDS-tPA trials have confirmed study findings of benefit of fibrinolytic therapy. A recent graphic analysis departed from best practices in the visual display of quantitative information by failing to take into account the skewed functional importance of NIH Stroke Scale raw scores and by scaling change axes at up to 20 times the range achievable by individual patients.

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