Modulation of Fate Determinants Olig2 and Pax6 in Resident Glia Evokes Spiking Neuroblasts in a Model of Mild Brain Ischemia | Zendy

Golo Kronenberg | Zendy; Karen Gertz | Zendy; Giselle Cheung | Zendy; Annalisa Buffo | Zendy; Helmut Kettenmann | Zendy; Magdalena Götz | Zendy; Matthias Endres | Zendy

Open Access

Modulation of Fate Determinants Olig2 and Pax6 in Resident Glia Evokes Spiking Neuroblasts in a Model of Mild Brain Ischemia

Author(s) -

Golo Kronenberg,

Karen Gertz,

Giselle Cheung,

Annalisa Buffo,

Helmut Kettenmann,

Magdalena Götz,

Matthias Endres

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.583039

Subject(s) - olig2 , medicine , neuroscience , striatum , pax6 , progenitor cell , subventricular zone , microbiology and biotechnology , biology , central nervous system , transcription factor , oligodendrocyte , stem cell , myelin , biochemistry , gene , dopamine

Although in vitro studies suggest that non-neurogenic regions of the adult central nervous system potentially contain multipotent parenchymal progenitors, neurons are clearly not replaced in most brain regions after injury. Here, in a well-established model of mild transient brain ischemia, we explored Olig2 antagonism and Pax6 overexpression as potential avenues to redirect endogenous progenitors proliferating in situ toward a neuronal fate.

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