A Mouse Model Characterizing Features of Vascular Dementia With Hippocampal Atrophy | Zendy

Keiko Nishio | Zendy; Masafumi Ihara | Zendy; Nobuyuki Yamasaki | Zendy; Raj N. Kalaria | Zendy; Takakuni Maki | Zendy; Youshi Fujita | Zendy; Hidefumi Ito | Zendy; Naoya Oishi | Zendy; Hidenao Fukuyama | Zendy; Tsuyoshi Miyakawa | Zendy; Ryōsuke Takahashi | Zendy; Hidekazu Tomimoto | Zendy

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A Mouse Model Characterizing Features of Vascular Dementia With Hippocampal Atrophy

Author(s) -

Keiko Nishio,

Masafumi Ihara,

Nobuyuki Yamasaki,

Raj N. Kalaria,

Takakuni Maki,

Youshi Fujita,

Hidefumi Ito,

Naoya Oishi,

Hidenao Fukuyama,

Tsuyoshi Miyakawa,

Ryōsuke Takahashi,

Hidekazu Tomimoto

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.581686

Subject(s) - medicine , hippocampal formation , cerebral blood flow , vascular dementia , dementia , atrophy , fluorodeoxyglucose , common carotid artery , pathology , positron emission tomography , cardiology , ischemia , nuclear medicine , carotid arteries , disease

We have previously described effects of chronic cerebral hypoperfusion in mice with bilateral common carotid artery stenosis (BCAS) using microcoils for 30 days. These mice specifically exhibit working memory deficits attributable to frontal-subcortical circuit damage without apparent gray matter changes, indicating similarities with subcortical ischemic vascular dementia. However, as subcortical ischemic vascular dementia progresses over time, the longer-term effects that characterize the mouse model are not known.

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