Protective Effect of High-Density Lipoprotein-Based Therapy in a Model of Embolic Stroke | Zendy

Bertrand Lapergue | Zendy; Juan Antonio Moreno | Zendy; Bao Quoc Dang | Zendy; Michèle Coutard | Zendy; Sandrine Delbosc | Zendy; Guy Raphaeli | Zendy; Nathalie Augè | Zendy; Isabelle Klein | Zendy; Mikaël Mazighi | Zendy; JeanBaptiste Michel | Zendy; Pierre Amarenco | Zendy; Olivier Meilhac | Zendy

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Protective Effect of High-Density Lipoprotein-Based Therapy in a Model of Embolic Stroke

Author(s) -

Bertrand Lapergue,

Juan Antonio Moreno,

Bao Quoc Dang,

Michèle Coutard,

Sandrine Delbosc,

Guy Raphaeli,

Nathalie Augè,

Isabelle Klein,

Mikaël Mazighi,

JeanBaptiste Michel,

Pierre Amarenco,

Olivier Meilhac

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.581512

Subject(s) - medicine , neuroprotection , saline , stroke (engine) , ischemia , anesthesia , brain ischemia , blood–brain barrier , endocrinology , central nervous system , mechanical engineering , engineering

High-density lipoprotein (HDL) levels are inversely associated with stroke incidence, suggesting a protective effect. Using a rat model, we tested the hypothesis that HDL exerts direct vasculo-/neuroprotective effects when administered during the acute phase of embolic stroke.

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