Preservation of GABA A Receptor Function by PTEN Inhibition Protects Against Neuronal Death in Ischemic Stroke | Zendy

Baosong Liu | Zendy; Lijun Li | Zendy; Quanguang Zhang | Zendy; Ning Chang | Zendy; Dianshi Wang | Zendy; Yuexin Shan | Zendy; Lei Li | Zendy; Hanbin Wang | Zendy; Hua Feng | Zendy; Liang Zhang | Zendy; Darrell W. Brann | Zendy; Qi Wan | Zendy

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Preservation of GABA _A Receptor Function by PTEN Inhibition Protects Against Neuronal Death in Ischemic Stroke

Author(s) -

Baosong Liu,

Lijun Li,

Quanguang Zhang,

Ning Chang,

Dianshi Wang,

Yuexin Shan,

Lei Li,

Hanbin Wang,

Hua Feng,

Liang Zhang,

Darrell W. Brann,

Qi Wan

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.579011

Subject(s) - pten , tensin , neuroprotection , gene knockdown , downregulation and upregulation , medicine , hippocampal formation , neuron , neuroscience , pharmacology , cancer research , microbiology and biotechnology , pi3k/akt/mtor pathway , biology , signal transduction , apoptosis , biochemistry , gene

Downregulation of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), is thought to be a novel neuroprotective strategy in ischemic stroke, but the underlying mechanisms remain unclear. In this study, we aimed to validate the use of PTEN regulation of gamma-aminobutyric acid subtype A receptors (GABA(A)Rs) as a molecular target for the treatment of ischemic stroke. Because suppression of GABA(A)Rs contributes to ischemic neuron death, describing the intracellular signaling that interacts with GABA(A)Rs in ischemic neurons would provide a molecular basis for novel stroke therapies.

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