Stem Cell–Derived Neurons Grafted in the Striatum Are Expelled Out of the Brain After Chronic Cortical Stroke | Zendy

Michel DuboisDauphin | Zendy; S. Julien | Zendy

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Stem Cell–Derived Neurons Grafted in the Striatum Are Expelled Out of the Brain After Chronic Cortical Stroke

Author(s) -

Michel DuboisDauphin,

S. Julien

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.578427

Subject(s) - striatum , neural stem cell , embryonic stem cell , medicine , neuroscience , cerebral cortex , atrophy , stroke (engine) , cortex (anatomy) , neurogenesis , lesion , stem cell , pathology , biology , microbiology and biotechnology , dopamine , mechanical engineering , biochemistry , gene , engineering

In humans and rodents, cortical stroke can lead to cortex atrophy in long-term survivors. In the rodent, fetal brain neural precursors or stem cell-derived neurons grafted in the stroke-lesioned brain integrate successfully and reduce infarct in the short term. We have examined the fate, in the long term, of mouse embryonic stem cell-derived neural precursors grafted after permanent middle cerebral artery occlusion in mice.

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