Intra-Arterial Iodinated Radiographic Contrast Material Injection Administration in a Rat Middle Cerebral Artery Occlusion and Reperfusion Model | Zendy

Yuko Kurosawa | Zendy; Aigang Lu | Zendy; Pooja Khatri | Zendy; Janice Carrozzella | Zendy; Joseph F. Clark | Zendy; Jane Khoury | Zendy; Thomas A. Tomsick | Zendy

Open Access

Intra-Arterial Iodinated Radiographic Contrast Material Injection Administration in a Rat Middle Cerebral Artery Occlusion and Reperfusion Model

Author(s) -

Yuko Kurosawa,

Aigang Lu,

Pooja Khatri,

Janice Carrozzella,

Joseph F. Clark,

Jane Khoury,

Thomas A. Tomsick

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.578245

Subject(s) - medicine , intracerebral hemorrhage , heparin , saline , occlusion , iodinated contrast , stroke (engine) , middle cerebral artery , perfusion , anesthesia , perfusion scanning , placebo , ischemia , surgery , pathology , subarachnoid hemorrhage , mechanical engineering , computed tomography , alternative medicine , engineering

Observations in human interventional stroke treatment led us to hypothesize that iodinated radiographic contrast material use may contribute to intracerebral hemorrhage. Effects of intra-arterial iodinated radiographic contrast material on hemorrhagic transformation after middle cerebral artery occlusion and reperfusion were studied in a placebo-controlled, blinded preclinical study in rats.

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