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Diffusion-Weighted Imaging and Cognition in the Leukoariosis and Disability in the Elderly Study
Author(s) -
Reinhold Schmidt,
Stefan Ropele,
José M. Ferro,
Sofia Madureira,
Ana Verdelho,
Katja Petrovic,
Alida A. Gouw,
Wiesje M. van der Flier,
Christian Enzinger,
Leonardo Pantoni,
Domenico Inzitari,
Timo Erkinjuntti,
Philip Scheltens,
LarsOlof Wahlund,
Gunhild Waldemar,
Egill Rostrup,
Anders Wallin,
Frederik Barkhof,
Franz Fazekas
Publication year - 2010
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.109.576629
Subject(s) - medicine , hyperintensity , cognition , atrophy , diffusion mri , brain size , effects of sleep deprivation on cognitive performance , white matter , magnetic resonance imaging , lesion , cognitive decline , cardiology , audiology , neuroscience , pathology , radiology , psychiatry , psychology , dementia , disease
The mechanisms by which leukoariosis impacts on clinical and cognitive functions are not yet fully understood. We hypothesized that ultrastructural abnormalities of the normal-appearing brain tissue (NABT) assessed by diffusion-weighted imaging played a major and independent role.

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