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Off-Label Thrombolysis Is Not Associated With Poor Outcome in Patients With Stroke
Author(s) -
Atte Meretoja,
Jukka Putaala,
Turgut Tatlisumak,
Sari Atula,
Ville Artto,
Sami Curtze,
Olli Häppölä,
Perttu J. Lindsberg,
Satu Mustanoja,
Katja Piironen,
Janne Pitkäniemi,
Kirsi Rantanen,
Tiina Sairanen,
Oili Salonen,
Heli Silvennoinen,
Lauri Soinne,
Daniel Strbian,
Marjaana Tiainen,
Markku Kaste
Publication year - 2010
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.109.576140
Subject(s) - medicine , thrombolysis , stroke (engine) , cardiology , myocardial infarction , mechanical engineering , engineering
Numerous contraindications included in the license of alteplase, most of which are not based on scientific evidence, restrict the portion of patients with acute ischemic stroke eligible for treatment with alteplase. We studied whether off-label thrombolysis was associated with poorer outcome or increased rates of symptomatic intracerebral hemorrhage compared with on-label use.

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