Effects of Granulocyte-Colony Stimulating Factor After Stroke in Aged Rats | Zendy

Aurel PopaWagner | Zendy; K. Stöcker | Zendy; Tudor Adrian Bălşeanu | Zendy; Andreas Rogalewski | Zendy; Kai Diederich | Zendy; Jens Minnerup | Zendy; Claudiu Mărgăritescu | Zendy; WolfRüdiger Schäbitz | Zendy

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Effects of Granulocyte-Colony Stimulating Factor After Stroke in Aged Rats

Author(s) -

Aurel PopaWagner,

K. Stöcker,

Tudor Adrian Bălşeanu,

Andreas Rogalewski,

Kai Diederich,

Jens Minnerup,

Claudiu Mărgăritescu,

WolfRüdiger Schäbitz

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.575621

Subject(s) - medicine , neurogenesis , subventricular zone , neuroprotection , granulocyte colony stimulating factor , stroke (engine) , dentate gyrus , lesion , environmental enrichment , hippocampus , anesthesia , ischemia , endocrinology , pathology , neuroscience , stem cell , chemotherapy , neural stem cell , psychology , biology , mechanical engineering , genetics , engineering

In aged humans, stroke is a major cause of disability for which no neuroprotective measures are available. Granulocyte-colony stimulating factor (G-CSF), a member of the cytokine family of growth factors, promotes brain neurogenesis and improves functional outcome after stroke in young animals. We tested the hypothesis that G-CSF provides a restorative therapeutic benefit in aged animals.

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