Stroke Subtype Classification to Mechanism-Specific and Undetermined Categories by TOAST, A-S-C-O, and Causative Classification System | Zendy

Michael Marnane | Zendy; Caroline A. Duggan | Zendy; Orla C. Sheehan | Zendy; Áine Merwick | Zendy; Niamh Han | Zendy; D. Curtin | Zendy; Dawn Harris | Zendy; Emma B. Williams | Zendy; Gillian Horgan | Zendy; Lorraine Kyne | Zendy; Patricia McCormack | Zendy; Joseph Duggan | Zendy; Alan Moore | Zendy; Gloria Crispino-O’Connell | Zendy; Peter J. Kelly | Zendy

Open Access

Stroke Subtype Classification to Mechanism-Specific and Undetermined Categories by TOAST, A-S-C-O, and Causative Classification System

Author(s) -

Michael Marnane,

Caroline A. Duggan,

Orla C. Sheehan,

Áine Merwick,

Niamh Han,

D. Curtin,

Dawn Harris,

Emma B. Williams,

Gillian Horgan,

Lorraine Kyne,

Patricia McCormack,

Joseph Duggan,

Alan Moore,

Gloria Crispino-O’Connell,

Peter J. Kelly

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.575373

Subject(s) - medicine , stroke (engine) , population , relative risk , embolism , disease , clinical trial , confidence interval , mechanical engineering , environmental health , engineering

Reliable etiologic classification of ischemic stroke may enhance clinical trial design and identification of subtype-specific environmental and genetic risk factors. Although new classification systems (Causative Classification System [CCS] and ASCO [A for atherosclerosis, S for small vessel disease, C for cardiac source, O for other cause]) have been developed to improve subtype assignment, few comparative data exist from large studies. We hypothesized that both CCS and ASCO would reduce the proportion of patients classified as cause undetermined compared with the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) scheme in a large population-based stroke study.

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