Augmented Superoxide Production By Nox2-Containing NADPH Oxidase Causes Cerebral Artery Dysfunction During Hypercholesterolemia | Zendy

Alyson A. Miller | Zendy; T. Michael De Silva | Zendy; Courtney P Judkins | Zendy; Henry Diep | Zendy; Grant R. Drummond | Zendy; Christopher G. Sobey | Zendy

Open Access

Augmented Superoxide Production By Nox2-Containing NADPH Oxidase Causes Cerebral Artery Dysfunction During Hypercholesterolemia

Author(s) -

Alyson A. Miller,

T. Michael De Silva,

Courtney P Judkins,

Henry Diep,

Grant R. Drummond,

Christopher G. Sobey

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.575365

Subject(s) - superoxide , cerebral arteries , endocrinology , medicine , nitric oxide synthase , nitric oxide , superoxide dismutase , apolipoprotein e , nadph oxidase , middle cerebral artery , oxidative stress , biochemistry , biology , ischemia , enzyme , disease

We tested the hypothesis that elevated superoxide production by Nox2-NADPH oxidase occurs in cerebral arteries during hypercholesterolemia and causes decreased nitric oxide function.

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