Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting in Neonatal Hypoxic–Ischemic Brain Injury | Zendy

Marcel M. Daadi | Zendy; Alexis S. Davis | Zendy; Ahmet Arac | Zendy; Zongjin Li | Zendy; Anne-Lise Maag | Zendy; Rishi Bhatnagar | Zendy; Kewen Jiang | Zendy; Guohua Sun | Zendy; Joseph C. Wu | Zendy; Gary K. Steinberg | Zendy

Open Access

Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting in Neonatal Hypoxic–Ischemic Brain Injury

Author(s) -

Marcel M. Daadi,

Alexis S. Davis,

Ahmet Arac,

Zongjin Li,

Anne-Lise Maag,

Rishi Bhatnagar,

Kewen Jiang,

Guohua Sun,

Joseph C. Wu,

Gary K. Steinberg

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.573691

Subject(s) - medicine , neuroscience , ischemic stroke , hypoxia (environmental) , microglia , sprouting , neural stem cell , ischemia , stem cell , pathology , cardiology , inflammation , microbiology and biotechnology , biology , chemistry , botany , organic chemistry , oxygen

Hypoxic-ischemic (HI) brain injury in newborn infants represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell-based therapy has the potential to rescue and replace the ischemic tissue caused by HI and to restore function. However, the mechanisms by which stem cell transplants induce functional recovery are yet to be elucidated. In the present study, we sought to investigate the efficacy of human neural stem cells derived from human embryonic stem cells in a rat model of neonatal HI and the mechanisms enhancing brain repair.

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