Glibenclamide Is Superior to Decompressive Craniectomy in a Rat Model of Malignant Stroke | Zendy

J. Marc Simard | Zendy; Natalia Tsymbalyuk | Zendy; Orest Tsymbalyuk | Zendy; Svetlana Ivanova | Zendy; Vladimir V. Yurovsky | Zendy; Volodymyr Gerzanich | Zendy

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Glibenclamide Is Superior to Decompressive Craniectomy in a Rat Model of Malignant Stroke

Author(s) -

J. Marc Simard,

Natalia Tsymbalyuk,

Orest Tsymbalyuk,

Svetlana Ivanova,

Vladimir V. Yurovsky,

Volodymyr Gerzanich

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.572644

Subject(s) - medicine , decompressive craniectomy , stroke (engine) , glibenclamide , surgery , anesthesia , traumatic brain injury , diabetes mellitus , psychiatry , mechanical engineering , engineering , endocrinology

Treating patients with malignant cerebral infarctions remains a major unsolved problem in medicine. Decompressive craniectomy (DC) improves the bleak outlook but is suboptimal. Using a rat model of severe ischemia/reperfusion with very high mortality due to malignant cerebral edema, we tested the hypothesis that blocking of sulfonylurea receptor 1-regulated NC(Ca-ATP) channels with glibenclamide would compare favorably to DC when reperfusion and treatment were begun 6 hours after onset of ischemia.

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