Enhanced Oligodendrogenesis and Recovery of Neurological Function by Erythropoietin After Neonatal Hypoxic/Ischemic Brain Injury | Zendy

Masanori Iwai | Zendy; R. Anne Stetler | Zendy; Juan Xing | Zendy; Xiaoming Hu | Zendy; Yanqin Gao | Zendy; Wenting Zhang | Zendy; Jun Chen | Zendy; Guodong Cao | Zendy

Open Access

Enhanced Oligodendrogenesis and Recovery of Neurological Function by Erythropoietin After Neonatal Hypoxic/Ischemic Brain Injury

Author(s) -

Masanori Iwai,

R. Anne Stetler,

Juan Xing,

Xiaoming Hu,

Yanqin Gao,

Wenting Zhang,

Jun Chen,

Guodong Cao

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.570325

Subject(s) - medicine , erythropoietin , white matter , neurogenesis , neuroprotection , hypoxia (environmental) , ischemia , anesthesia , neuroscience , magnetic resonance imaging , biology , chemistry , organic chemistry , oxygen , radiology

Neuronal replacement has recently gained attention as a potential therapeutic target under ischemic conditions. However, the oligodendrogenic infrastructure is equally critical for restoration of brain function and is also sensitive to ischemic injury. Erythropoietin (EPO) is a neuroprotective molecule that stimulates neuronal replacement after neonatal hypoxia/ischemia (H/I) when delivered soon after the onset of reperfusion. Because EPO can improve recovery of neurological function in the absence of tissue protection, we hypothesize that EPO may improve neurological function via enhancement of white matter recovery after H/I. Thus, we sought to determine the effects of delayed administration of EPO on white matter injury and recovery of neurological function after neonatal H/I.

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