Open AccessDeferoxamine Treatment for Intracerebral Hemorrhage in Aged Rats
Author(s) -
Masanobu Okauchi,
Ya Hua,
Richard F. Keep,
Lewis B. Morgenstern,
Timothy Schallert,
Guohua Xi
Publication year - 2010
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.109.569830
Subject(s) - medicine , intracerebral hemorrhage , atrophy , deferoxamine , anesthesia , therapeutic effect , edema , subarachnoid hemorrhage
Deferoxamine (DFX) reduces brain edema, neurological deficits, and brain atrophy after intracerebral hemorrhage (ICH) in aged and young rats. Our previous study found that 50 mg/kg is an effective dose in aged rats. In the present study, we explored potential therapeutic time windows and optimal therapeutic durations.
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