Genome-Wide Association Studies of MRI-Defined Brain Infarcts | Zendy

Stéphanie Debette | Zendy; Joshua C. Bis | Zendy; Myriam Fornage | Zendy; Helena Schmidt | Zendy; M. Arfan Ikram | Zendy; Sigurður Sigurðsson | Zendy; Gerardo Heiss | Zendy; Maksim Struchalin | Zendy; Albert V. Smith | Zendy; Aad van der Lugt | Zendy; Charles DeCarli | Zendy; Thomas Lumley | Zendy; David S. Knopman | Zendy; Christian Enzinger | Zendy; Gudny Eiriksdottir | Zendy; Peter J. Koudstaal | Zendy; Anita L. DeStefano | Zendy; Bruce M. Psaty | Zendy; Carole Dufouil | Zendy; Diane Catellier | Zendy; Franz Fazekas | Zendy; Thor Aspelund | Zendy; Yurii S. Aulchenko | Zendy; Alexa S. Beiser | Zendy; Jerome I. Rotter | Zendy; Christophe Tzourio | Zendy; Dean Shibata | Zendy; Maria Tscherner | Zendy; Tamara B. Harris | Zendy; Fernando Rivadeneira | Zendy; Larry D. Atwood | Zendy; Kenneth Rice | Zendy; Rebecca F. Gottesman | Zendy; Mark A. van Buchem | Zendy; André G. Uitterlinden | Zendy; Margaret KellyHayes | Zendy; Mary Cushman | Zendy; YiCheng Zhu | Zendy; Eric Boerwinkle | Zendy; Vilmundur Guðnason | Zendy; Albert Hofman | Zendy; José R. Romero | Zendy; Lorna M. Lopez | Zendy; Cornelia M. van Duijn | Zendy; Rhoda Au | Zendy; Susan R. Heckbert | Zendy; Philip A. Wolf | Zendy; Thomas H. Mosley | Zendy; Sudha Seshadri | Zendy; Monique M.B. Breteler | Zendy; Reinhold Schmidt | Zendy; Lenore J. Launer | Zendy; W. T. Longstreth | Zendy

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Genome-Wide Association Studies of MRI-Defined Brain Infarcts

Author(s) -

Stéphanie Debette,

Joshua C. Bis,

Myriam Fornage,

Helena Schmidt,

M. Arfan Ikram,

Sigurður Sigurðsson,

Gerardo Heiss,

Maksim Struchalin,

Albert V. Smith,

Aad van der Lugt,

Charles DeCarli,

Thomas Lumley,

David S. Knopman,

Christian Enzinger,

Gudny Eiriksdottir,

Peter J. Koudstaal,

Anita L. DeStefano,

Bruce M. Psaty,

Carole Dufouil,

Diane Catellier,

Franz Fazekas,

Thor Aspelund,

Yurii S. Aulchenko,

Alexa S. Beiser,

Jerome I. Rotter,

Christophe Tzourio,

Dean Shibata,

Maria Tscherner,

Tamara B. Harris,

Fernando Rivadeneira,

Larry D. Atwood,

Kenneth Rice,

Rebecca F. Gottesman,

Mark A. van Buchem,

André G. Uitterlinden,

Margaret KellyHayes,

Mary Cushman,

YiCheng Zhu,

Eric Boerwinkle,

Vilmundur Guðnason,

Albert Hofman,

José R. Romero,

Lorna M. Lopez,

Cornelia M. van Duijn,

Rhoda Au,

Susan R. Heckbert,

Philip A. Wolf,

Thomas H. Mosley,

Sudha Seshadri,

Monique M.B. Breteler,

Reinhold Schmidt,

Lenore J. Launer,

W. T. Longstreth

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.569194

Subject(s) - genome wide association study , medicine , minor allele frequency , genetic association , single nucleotide polymorphism , odds ratio , linkage disequilibrium , genetics , population , pathology , genotype , biology , gene , environmental health

Previous studies examining genetic associations with MRI-defined brain infarct have yielded inconsistent findings. We investigated genetic variation underlying covert MRI infarct in persons without histories of transient ischemic attack or stroke. We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

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