Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats | Zendy

Yu Hasegawa | Zendy; Hidenori Suzuki | Zendy; Takumi Sozen | Zendy; William Rolland | Zendy; John H. Zhang | Zendy

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Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

Author(s) -

Yu Hasegawa,

Hidenori Suzuki,

Takumi Sozen,

William Rolland,

John H. Zhang

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.568899

Subject(s) - medicine , neuroprotection , stroke (engine) , ischemic stroke , sphingosine 1 phosphate , sphingosine 1 phosphate receptor , sphingosine , receptor , pharmacology , anesthesia , neuroscience , ischemia , mechanical engineering , engineering , biology

FTY720 is a known sphingosine 1-phosphate receptor agonist. In the present study, we investigated the neuroprotective effect of postischemic administration of FTY720 in rats with 2 hours transient middle cerebral artery occlusion (MCAO).

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