Genetically Reduced Soluble Epoxide Hydrolase Activity and Risk of Stroke and Other Cardiovascular Disease | Zendy

Julie Lee | Zendy; Morten Dahl | Zendy; Peer Grande | Zendy; Anne TybjærgHansen | Zendy; Børge G. Nordestgaard | Zendy

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Genetically Reduced Soluble Epoxide Hydrolase Activity and Risk of Stroke and Other Cardiovascular Disease

Author(s) -

Julie Lee,

Morten Dahl,

Peer Grande,

Anne TybjærgHansen,

Børge G. Nordestgaard

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.567768

Subject(s) - medicine , stroke (engine) , disease , vascular disease , cardiology , mechanical engineering , engineering

The development of stroke has been linked to lowered levels of epoxyeicosatrienoic acids in the cerebral microvasculature. These substances are metabolized by the enzyme-soluble epoxide hydrolase encoded by the EPHX2 gene. We tested whether genetically reduced soluble epoxide hydrolase activity is associated with risk of ischemic stroke, myocardial infarction, and ischemic heart disease.

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